4fgl

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Reduced quinone reductase 2 in complex with chloroquineReduced quinone reductase 2 in complex with chloroquine

Structural highlights

4fgl is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Gene:NMOR2, NQO2 (Homo sapiens)
Activity:Ribosyldihydronicotinamide dehydrogenase (quinone), with EC number 1.10.99.2
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[NQO2_HUMAN] The enzyme apparently serves as a quinone reductase in connection with conjugation reactions of hydroquinones involved in detoxification pathways as well as in biosynthetic processes such as the vitamin K-dependent gamma-carboxylation of glutamate residues in prothrombin synthesis.[1]

See Also

References

  1. ↑ Calamini B, Santarsiero BD, Boutin JA, Mesecar AD. Kinetic, thermodynamic and X-ray structural insights into the interaction of melatonin and analogues with quinone reductase 2. Biochem J. 2008 Jul 1;413(1):81-91. PMID:18254726 doi:10.1042/BJ20071373

4fgl, resolution 1.20Å

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