4fox

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Crystal Structure of Mtb ThyA in complex with dUMP and RaltitrexedCrystal Structure of Mtb ThyA in complex with dUMP and Raltitrexed

Structural highlights

4fox is a 8 chain structure with sequence from Mycobacterium tuberculosis h37rv. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Gene:MT2834, MTV002.29c, Rv2764c, thyA (Mycobacterium tuberculosis H37Rv)
Activity:Thymidylate synthase, with EC number 2.1.1.45
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[TYSY_MYCTU] Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity).

See Also

4fox, resolution 2.30Å

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