4wab

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Crystal structure of mPGES1 solved by native-SAD phasingCrystal structure of mPGES1 solved by native-SAD phasing

Structural highlights

4wab is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:,
Activity:Prostaglandin-E synthase, with EC number 5.3.99.3
Resources:FirstGlance, OCA, RCSB, PDBsum

Function

[PTGES_HUMAN] Catalyzes the oxidoreduction of prostaglandin endoperoxide H2 (PGH2) to prostaglandin E2 (PGE2).[1]

References

  1. ↑ Jegerschold C, Pawelzik SC, Purhonen P, Bhakat P, Gheorghe KR, Gyobu N, Mitsuoka K, Morgenstern R, Jakobsson PJ, Hebert H. Structural basis for induced formation of the inflammatory mediator prostaglandin E2. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11110-5. Epub 2008 Aug 5. PMID:18682561 doi:0802894105

4wab, resolution 2.70Å

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OCA
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