1ok8

Crystal structure of the dengue 2 virus envelope glycoprotein in the postfusion conformationCrystal structure of the dengue 2 virus envelope glycoprotein in the postfusion conformation

Structural highlights 1ok8 is a 1 chain structure with sequence from Dengue virus 2. The July 2008 RCSB PDB Molecule of the Month feature on Dengue Virus by David Goodsell is 10.2210/rcsb_pdb/mom_2008_7. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: , Related: 1l9k, 1oam, 1oan Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed Dengue virus enters a host cell when the viral envelope glycoprotein, E, binds to a receptor and responds by conformational rearrangement to the reduced pH of an endosome. The conformational change induces fusion of viral and host-cell membranes. A three-dimensional structure of the soluble E ectodomain (sE) in its trimeric, postfusion state reveals striking differences from the dimeric, prefusion form. The elongated trimer bears three 'fusion loops' at one end, to insert into the host-cell membrane. Their structure allows us to model directly how these fusion loops interact with a lipid bilayer. The protein folds back on itself, directing its carboxy terminus towards the fusion loops. We propose a fusion mechanism driven by essentially irreversible conformational changes in E and facilitated by fusion-loop insertion into the outer bilayer leaflet. Specific features of the folded-back structure suggest strategies for inhibiting flavivirus entry. Structure of the dengue virus envelope protein after membrane fusion.,Modis Y, Ogata S, Clements D, Harrison SC Nature. 2004 Jan 22;427(6972):313-9. PMID:14737159 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 1ok8, resolution 2.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image