X-ray structure of the adduct between hen egg white lysozyme and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centersX-ray structure of the adduct between hen egg white lysozyme and Auoxo6, a dinuclear gold(III) complex with -dioxo bridges linking the two metal centers

Structural highlights

4lfx is a 1 chain structure with sequence from Chick. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:, ,
Activity:Lysozyme, with EC number 3.2.1.17
Resources:FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

The interactions between a few representative gold-based drugs and hen egg white lysozyme were studied by X-ray crystallography. High resolution crystal structures solved for three metallodrug-protein adducts provide valuable insight into the molecular mechanism of these promising metal compounds and the inherent protein metalation processes.

The mode of action of anticancer gold-based drugs: a structural perspective.,Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A Chem Commun (Camb). 2013 Sep 18. PMID:24045294[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. Messori L, Scaletti F, Massai L, Cinellu MA, Gabbiani C, Vergara A, Merlino A. The mode of action of anticancer gold-based drugs: a structural perspective. Chem Commun (Camb). 2013 Sep 18. PMID:24045294 doi:10.1039/c3cc46400h

4lfx, resolution 2.10Å

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