4c53

Crystal Structure of Guanarito virus GP2 in the post-fusion conformationCrystal Structure of Guanarito virus GP2 in the post-fusion conformation

Structural highlights

4c53 is a 3 chain structure with sequence from Gtov. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Resources:	FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

Guanarito virus (GTOV) is an emergent and deadly pathogen. We present the crystal structure of the glycosylated GTOV fusion glycoprotein to 4.1 A-resolution, in the post-fusion conformation. Our structure reveals a classical six-helix bundle and presents direct verification that New World arenaviruses exhibit class-I viral membrane fusion machinery. The structure provides visualization of an N-linked glycocalyx coat and consideration of glycan dynamics reveals extensive coverage of the underlying protein surface, following virus-host membrane fusion.

Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation.,Parsy ML, Harlos K, Huiskonen JT, Bowden TA J Virol. 2013 Sep 18. PMID:24049182^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Parsy ML, Harlos K, Huiskonen JT, Bowden TA. Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation. J Virol. 2013 Sep 18. PMID:24049182 doi:10.1128/JVI.02298-13

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OCA

[1] Parsy ML, Harlos K, Huiskonen JT, Bowden TA. Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 post-fusion architecture with extensive glycosylation. J Virol. 2013 Sep 18. PMID:24049182 doi:10.1128/JVI.02298-13

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