3e77
Human phosphoserine aminotransferase in complex with PLPHuman phosphoserine aminotransferase in complex with PLP
Structural highlights
Disease[SERC_HUMAN] Defects in PSAT1 are the cause of phosphoserine aminotransferase deficiency (PSATD) [MIM:610992]. PSATD is characterized biochemically by low plasma and cerebrospinal fluid concentrations of serine and glycine and clinically by intractable seizures, acquired microcephaly, hypertonia, and psychomotor retardation.[1] Function[SERC_HUMAN] Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. See AlsoReferences
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OCACategories:
- Homo sapiens
- Phosphoserine transaminase
- Andersson, J
- Arrowsmith, C H
- Berg, S Van Den
- Berglund, H
- Bountra, C
- Collins, R
- Dahlgren, L G
- Edwards, A M
- Flodin, S
- Flores, A
- Graslund, S
- Hammarstrom, M
- Johansson, A
- Johansson, I
- Karlberg, T
- Kotenyova, T
- Lehtio, L
- Moche, M
- Nilsson, M E
- Nordlund, P
- Nyman, T
- Olesen, K
- Persson, C
- Structural genomic
- Sagemark, J
- Schueler, H
- Thorsell, S G
- Tresaugues, L
- Weigelt, J
- Welin, M
- Wikstrom, M
- Wisniewska, M
- Amino-acid biosynthesis
- Aminotransferase
- Disease mutation
- Phosphoserine aminotransferase
- Plp
- Pyridoxal phosphate
- Serc
- Serine biosynthesis
- Sgc
- Transferase