Tumor necrosis factor

Tumor necrosis factor (TNF) is a cytokine which can cause apoptosis. TNFα is implicated in tumor regression, septic shock, inflammation and cachexia (wasting syndrome). It is involved in the regulation of the immune cells. TNF is a transmembrane homotrimer. The soluble TNF is produced by cleavage by the metalloprotease TNF alpha converting enzyme (TACE or ADAM17 see A Disintegrin And Metalloproteinase).

spinqualitylabelsall models Structure of human tumor necrosis factor tetramer complex with inhibitor (PDB entry 2az5) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of tumor necrosis factor3D Structures of tumor necrosis factor

Updated on 16-December-2014

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• TNF alpha
  • 1tnf – hTNF – human
    
  • 2tun, 1a8m, 4tsv, 5tsw, 2e7e, 2zjc, 2zpx – hTNF (mutant)
    
  • 2tnf – TNF – mouse
    
  • 2az5 – hTNF + inhibitor
    
  • 3it8 – hTNF + poxvirus 2L protein
    
  • 3l9j – hTNF + antagonist
    
  • 3alq – hTNF (mutant) + TNF receptor
    
  • 4g3y, 3wd5 – hTNF + antibody
    
• TNF beta
  • 1tnr – hTNF + TNF receptor p55
    
• TNF
  • 2vfj – hTNF ovarian tumor domain