Stimulator of interferon genes

Stimulator of interferon genes (STING) induces production of type I interferon when cells are infected by viruses, mycobacteria and intracellular parasites. STING recognizes and binds cyclic-di-GMP produced by bacteria and cyclic-GMP AMP (cGAMP) produced by viruses. The C-terminal domain (CTD) (residues 139-379 in human) of STING binds cyclic-di-GMP. STING is a facilitator of innate immune signaling.

spinqualitylabelsall models Structure of human STING CTD complex with c-di-GMP (stick model) and Ca+2 ion (green) (PDB entry 4ef4) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of STING3D structures of STING

(Updated on 10-December-2014

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• Stimulator of interferon genes
  • 4ef5, 4f5w, 4f9e – hSTING CTD - human
    
  • 4f5e – hSTING CTD (mutant)
    
  • 4jc5, 4kc0 – mSTING CTD - mouse
    
• Stimulator of interferon genes complex with ligand
  • 4ef4, 4f5y, 4f9g – hSTING CTD + c-di-GMP
    
  • 4emt – hSTING residues 155-341 + c-di-GMP
    
  • 4f5d – hSTING CTD (mutant) + c-di-GMP
    
  • 4kby – mSTING CTD + c-di-GMP
    
  • 4ksy – hSTING CTD + cGAMP
    
  • 4loh, 4loi – hSTING CTD + c-di-GMP derivative
    
  • 4loj, 4lok – mSTING CTD + c-di-GMP derivative
    
  • 4lol – mSTING CTD + chemptherapeutic agent DMXAA