3nr6

Crystal structure of xenotropic murine leukemia virus-related virus (XMRV) proteaseCrystal structure of xenotropic murine leukemia virus-related virus (XMRV) protease

Structural highlights

3nr6 is a 2 chain structure with sequence from Viruses. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	,
Related:	2hvp, 4fiv, 2fmb, 2i1a, 2rsp
Gene:	gag-pol (Viruses)
Resources:	FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

Using energy and density guided Rosetta refinement to improve molecular replacement, we determined the crystal structure of the protease encoded by xenotropic murine leukemia virus-related virus (XMRV). Despite overall similarity of XMRV protease to other retropepsins, the topology of its dimer interface more closely resembles those of the monomeric, pepsin-like enzymes. Thus, XMRV protease may represent a distinct branch of the aspartic protease family.

Crystal structure of XMRV protease differs from the structures of other retropepsins.,Li M, Dimaio F, Zhou D, Gustchina A, Lubkowski J, Dauter Z, Baker D, Wlodawer A Nat Struct Mol Biol. 2011 Jan 23. PMID:21258323^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Li M, Dimaio F, Zhou D, Gustchina A, Lubkowski J, Dauter Z, Baker D, Wlodawer A. Crystal structure of XMRV protease differs from the structures of other retropepsins. Nat Struct Mol Biol. 2011 Jan 23. PMID:21258323 doi:10.1038/nsmb.1964

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Li M, Dimaio F, Zhou D, Gustchina A, Lubkowski J, Dauter Z, Baker D, Wlodawer A. Crystal structure of XMRV protease differs from the structures of other retropepsins. Nat Struct Mol Biol. 2011 Jan 23. PMID:21258323 doi:10.1038/nsmb.1964

[1]