1n4y
REFINED STRUCTURE OF KISTRIN
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| Gene: | RHOD (Calloselasma rhodostoma) | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
OverviewOverview
The structure of kistrin, which is a member of a homologous family of glycoprotein IIb-IIIa (GP IIb-IIIa) antagonists and potent protein inhibitors of platelet aggregation, has been determined by two-dimensional nuclear magnetic resonance (NMR) spectroscopy. The 68-residue protein consists of a series of tightly packed loops held together by six disulfide bonds and has almost no regular secondary structure. Kistrin has an Arg-Gly-Asp (RGD) adhesion site recognition sequence important for binding to GP IIb-IIIa that is located at the apex of a long loop across the surface of the protein.
About this StructureAbout this Structure
1N4Y is a Single protein structure of sequence from Calloselasma rhodostoma. This structure supersedes the now removed PDB entry 1KST. Full crystallographic information is available from OCA.
ReferenceReference
Solution structure of kistrin, a potent platelet aggregation inhibitor and GP IIb-IIIa antagonist., Adler M, Lazarus RA, Dennis MS, Wagner G, Science. 1991 Jul 26;253(5018):445-8. PMID:1862345
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