Ribonucleotide reductase

Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.

• Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.
  
• Class II RNR reduces ribonucleotide triphosphates using coenzyme B12.
  
• Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center.
  

For details on human RNR2 see P53R2. For mouse RNR see Mouse Ribonucleotide Reductase R2.

3D Structures of Ribonucleotide reductase3D Structures of Ribonucleotide reductase

Updated on 09-December-2014

{"openlevels":0}

• Class I ribonucleotide reductase
• Ribonucleotide reductase large subunit
  • 1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
    
  • 5r1r, 6r1r, 7r1r, 1r1r, 1rlr, 1mrr - EcRNR R1 – Escherichia coli
    
  • 4n82 – SsRNR – Streptococcus sanguinis
    
• Ribonucleotide reductase large subunit complex
  • 3hnc – hRNR M1 + TTP – human
    
  • 3hnd – hRNR M1 + GDP + TTP
    
  • 3hne, 3hnf – hRNR M1 + ATP + TTP
    
  • 2wgh - hRNR M1 + ATP + Mg
    
  • 3paw - yRNR R1 + ATP
    
  • 3k8t - yRNR R1 + ADP analog
    
  • 3s87 - yRNR R1 + ADP + GTP
    
  • 3s8a - yRNR R1 (mutant) + GTP
    
  • 3tba - yRNR R1 (mutant) + GTP + ADP
    
  • 3s8b - yRNR R1 + AMPPNP + CDP
    
  • 3s8c, 3tb9 - yRNR R1 (mutant) + AMPPNP + CDP
    
  • 2zlf, 2zlg - yRNR R1 + peptide
    
  • 2eud - yRNR R1 + ligand
    
  • 3rsr – yRNR + inhibitor
    
  • 2r1r - EcRNR R1 + TTP
    
  • 3r1r - EcRNR R1 + AMPPNP
    
  • 4r1r - EcRNR R1 + GDP + TTP
    
  • 1qfn - EcRNR R1 + glutaredoxin 1
    
  • 1peu - StRNR + DTP - Salmonella typhimurium
    
• RNR small subunit
  • 2xof, 3n37, 3n38, 2alx, 1piy, 1r65, 1mxr, 1jqc, 1jpr, 1av8, 1xik, 1rib, 4m1f – EcRNR R2
    
  • 1yfd, 1piz, 1pj0, 1pj1, 1pm2, 1pim, 1piu, 1biq, 2av8, 1pfr - EcRNR R2 (mutant)
    
  • 3hf1, 2vux, 2uw2, 4djn – hRNR M2
    
  • 3mjo, 3dhz, 1oqu, 1kgn, 1kgo, 1kgp – RNR R2 – Corynebacterium ammoniagenes
    
  • 2p1i – RNR R2 – Plasmodium yoelii
    
  • 2o1z - RNR R2 – Plasmodium vivax
    
  • 1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
    
  • 1smq, 1sms – yRNR 2
    
  • 4d8f, 4d8g, 4m1i - CtRNR R2 + Fe + Mn
    
  • 1syy - CtRNR R2 + Fe + Pb– Chlamydia trachomatis
    
  • 2ani - CtRNR R2 (mutant) + Fe + Pb
    
  • 4m1h - CtRNR R2
    
  • 4dr0 - RNR + Mn – Bacillus subtilis
    
  • 1uzr – RNR R2 – Mycobacterium tuberculosis
    
  • 3olj – hRNR M2
    
  • 1jk0 – yRNR Y2+Y4
    
  • 3vpm, 3vpn, 3vpo – hRNR M2 (mutant)
    
  • 2rcc – RNR – Bacillus halodurans
    
  • 4bmq, 4bmr, 4bmt - BcRNR + Fe – Bacillus cereus
    
  • 4bmu - BcRNR + Mn
    
  • 4n83 - SsRNR + Mn
    
• Ribonucleotide reductase small subunit complex
  • 1rsr, 1rsv - EcRNR R2 (mutant) + N3
    
  • 3n39, 3n3a, 3n3b – EcRNR R2 + NrdI
    
  • 1rnr – EcRNR R2 (mutant) + dopa
    
  • 1w69 – mRNR R2 + acetate
    
  • 4bmo, 4bmp - BcRNR + NRDI
    
• Ribonucleotide reductase small+large subunit
  • 3uus, 4erm - EcRNR R1+ R2
    
  • 4erp - EcRNR R1+ R2 + inhibitor
    
  • 2xak, 2xap, 2xo4, 2xo5 - EcRNR R1+ R2 peptide
    
  • 2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) + R2 peptide
    
  • 2bq1 - StRNR R1+ R2
• Class II ribonucleotide reductase
  • 1xjf – TmRNR + ATP – Thermotoga maritima
    
  • 1xjg - TmRNR + ATP-UDP
    
  • 1xjj - TmRNR + GTP
    
  • 1xjk - TmRNR + GTP-ADP
    
  • 1xjm - TmRNR + TTP
    
  • 1xje - TmRNR + TTP-GDP
    
  • 1xjn - TmRNR + ATP-CDP
    
  • 3o0n - TmRNR + TTP + Co + Mg + deoxyadenosine + B12
    
  • 3o0o - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12
    
  • 3o0q - TmRNR + TTP + GDP + Mg + adenosine
    
  • 1pem - StRNR R1
    
  • 1r2f, 2r2f - StRNR R2
    
  • 1peo, 1peq, 2peu - StRNR R1 + effector
    
  • 1l1l – RNR (mutant) – Lactobacillus leichmannii
    
• Class III ribonucleotide reductase
  • 1h78, 1h79, 1h7a, 1hk8 – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4
    
  • 1h7b – T4RNR (mutant)