Protein phosphatase

Protein phosphatases (PP) regular protein phosphorylation and thus are key in intracellular signal transduction processes.

• PP1 is a serine/threonine phosphatase.
  
• PP2A targets proteins in the oncogenic signaling pathways. For PP2A see also HEAT Repeat.
  
• PP2C are Mg/Mn- dependent and are essential for the regulation of cell cycle and stress signaling pathways.
  
• PP4 regulates a variety of cellular functions.
  
• PP5 is activated by lipids and is involved in signal transduction.

3D Structures of protein phosphatase3D Structures of protein phosphatase

Updated on 04-December-2014

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• Protein phosphatase 1A
  • 3fxj, 3fxk, 3fxl, 3fxm, 3fxo – hPP1A + Mn – human
    
  • 4da1 – hPP1K + Mn
    
  • 1jk7, 1u32, 2bcd, 2bdx, 3e7a, 3e7b – hPP1 catalytic subunit + tumor-inducing toxin
    
  • 1fjm – PP1 + tumor-inducing toxin - rabbit
    
  • 3egg – hPP1 catalytic subunit + spinophilin
    
  • 3hvq – hPP1 catalytic subunit + neuroabin
    
  • 3n5u – hPP1A catalytic subunit + retinoblastoma-associated protein
    
  • 3v4y – hPP1A catalytic subunit + PP1 nuclear inhibitor
    
  • 4g9j – hPP1A catalytic subunit + peptide
    
  • 3egh – hPP1 catalytic subunit + spinophilin + toxin
    
  • 1it6 – hPP1 catalytic subunit + calyculin
    
  • 1s70 – hPP1 catalytic subunit (mutant) + smooth muscle myosin phosphatase
    
  • 2o8a, 2o8g – PP1C catalytic subunit + inhibitor - rat
    
  • 2rlt – PP1 regulatory subunit – pig - NMR
    
• Protein phosphatase 2A
  • 1b3u, 2ixm, 2jak, 2g62 – hPP2A regulatory subunit
    
  • 2pkg – hPP2A regulatory subunit + small T antigen
    
  • 2pf4 – PP2A regulatory subunit + small T antigen - mouse
    
  • 2ie3, 2ie4, 2npp, 2nyl, 2nym, 2iae, 3dw8, 3k7v, 3k7w – hPP2A catalytic + regulatory subunit + tumor-inducing toxin
    
  • 3fga – hPP2C catalytic + regulatory subunit + tumor-inducing toxin + Sgo
    
  • 3c5w – hPP2A catalytic + regulatory subunit + PP2A-specific methyltransferase
    
  • 3p71 – hPP2A catalytic subunit + leucine carboxyl methyltransferase
    
• Protein phosphatase 2C
  • 1a6q – hPP2C
    
  • 2iq1 – hPP2C κ
    
  • 2p8e – hPP2C β
    
  • 2cm1 – PP2C + Mn – Mycobacterium tuberculosis
    
  • 3d8k – PP2C – Toxoplasma gondii
    
  • 3jrq, 3kdj, 3nmn – AtPP2C + Pyl1 – Arabidopsis thaliana
    
  • 3nmt, 3kb3, 3nmv, 3ujl – AtPP2C + Pyl2
    
  • 4la7, 4lg5, [4lga]], 4lgb – AtPP2C + Pyl2 + ligand
    
  • 4ds8 – AtPP2C + Pyl3 + Mn
    
  • 3rt0 – AtPP2C (mutant) + Pyl10
    
  • 4n0g – AtPP2C + Pyl13
    
  • 3qn1, 3zvu – AtPP2C + Pyr1
    
  • 3ujg – AtPP2C + SNRK2
    
  • 3ujk – AtPP2C
    
• Protein phosphatase 5
  • 1s95 – hPP5 catalytic domain
    
  • 2g62 – hPP5
    
  • 2bug – hPP5 tetratricopeptide domain + Hsp90 peptide
    
  • 3h60 – hPP5 catalytic domain + Mn
    
  • 3h61, 3h62, 3h63, 3h64 – hPP5 catalytic domain + Mn + inhibitor
    
  • 3h66 – hPP5 catalytic domain + Zn
    
  • 3h67, 3h68, 3h69 – hPP5 catalytic domain + Zn + inhibitor