Cas9

Cas9 is the RNA-guided DNA endonuclease used by the CRISPR-associated systems to generate double-strand DNA breaks in the invading DNA during an adaptive bacterial immune response.

It has been exploited for use in genome editing systems.

Articles in Proteopedia concerning Cas9 include:

• any?

3D structures of Cas93D structures of Cas9

• [[4un3], 4un4, and 4un5 - S. pyogenes Cas9 bound to sgRNA and target DNA
• 4oo8
• 4cmp
• 4cmq - Mn²⁺-bound S. pyogenes Cas9

Actinomyces naeslundii Cas9Actinomyces naeslundii Cas9

• 4oge
• 4ogc - Mn²⁺-bound A.s naeslundii Cas9

See AlsoSee Also

HNH endonuclease