Growth factor receptor-bound protein

<StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry 1tze)' scene=>

Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains.

• GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.
  
• GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.
  
• GRB10 interacts with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see Grb10 SH2 Domain.
  

3D structures of Grb3D structures of Grb

Updated on 26-November-2014

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• GRB2
  • 1gri, 2h46 – hGRB2 – human
    
• GRB2 C terminal SH3 domain
  • 1gfc, 1gfd – hGRB2 C terminal SH3 domain - NMR
    
  • 2vvk, 2vwf, 2w0z – hGRB2 C terminal SH3 domain
    
  • 1io6 – hGRB2 C terminal SH3 domain + ligand peptide - NMR
    
  • 1gcq – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain
    
• GRB2 N terminal SH3 domain
  • 1gbr, 1gbq, 2gbq, 3gbq, 4gbq – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR
    
  • 1aze – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR
    
• GRB2 SH2 domain
  • 1jyu – hGRB2 SH2 domain
    
  • 1ghu – hGRB2 SH2 domain (mutant) - NMR
    
  • 1fhs – hGRB2 SH2 domain - NMR
    
  • 1x0n – hGRB2 SH2 domain + inhibitor - NMR
    
  • 2huw – hGRB2 SH2 domain + cyclopropane derivative
    
  • 1cj1 – hGRB2 SH2 domain + phosphor-Tyr derivative
    
  • 2aoa, 2aob – hGRB2 SH2 domain + peptide mimetic
    
  • 1tze, 1bmb, 1bm2, 1zfp, 1fyr, 1jyq, 1jyr, 2h5k, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8l, 3s8n, 3s8o, 1zfp – hGRB2 SH2 domain + phosphor-Tyr peptide
    
  • 1qg1 – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR
    
  • 3wa4 - hGRB2 SH2 domain + CD28 peptide
    
• GRB4
  • 4e6r – hGRB4 C terminal SH3 domain
    
• GRB7
  • 2qms – hGRB7 SH2 domain
    
  • 1mw4, 2l4k – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR
    
  • 3pqz – hGRB7 SH2 domain + cyclic peptide
    
  • 1wgr – hGRB7 RA domain - NMR
    
• GRB10
  • 1nrv – hGRB10 SH2 domain
    
  • 3m7f – hGRB10 SH2 domain + NEDD4 C2 domain
    
  • 3hk0 – hGRB10 RA and PH domains
    
• GRB14
  • 2aug – hGRB14 SH2 domain
    
  • 2auh – hGRB14 BPS domain + insulin receptor kinase domain
    
  • 4k81 – hGRB14 RA and PH domains + GTPase Hras