Exportin

Function Exportins (XPO) mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. XPO-t exports tRNA from the nucleus.

spinqualitylabelsall models Structure of yeast exportin-5 (dark green and dark red) complex with GTPaseRan (pale green and pink), Mg+2 (green) and RNA (PDB code 3icq). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D structures of exportin3D structures of exportin

Updated on 24-November-2014

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• XPO-1
  • 4bsm, 4bsn – hXPO – human
    
  • 1w9c – hXPO C terminal 6 heat repeats
    
  • 3vyc – yXPO (mutant) - yeast
• XPO-1 complexes
  • 3gb8 – hXPO + RNA U transporter 1
    
  • 3gjx – hXPO + RNA U transporter 1 + GTPaseRan
    
  • 3m1i, 4gpt, 4gmx, 4hat, 4hb2 – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein
    
  • 4hau, 4hav, 4haw, 4hax, 4hay, 4haz, 4hb0, 4hb3, 4hb4 – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein + antibiotic
    
  • 3nby, 3nbz, 3nc0 – mXPO + RNA U transporter 1 + GTPaseRan - mouse
    
  • 3nc1 – mXPO + GTPaseRan
    
  • 2l1l – hXPO residues 504-630 + cAMP-dependent protein kinase inhibitor α - NMR
    
• XPO-t
  • 3ibv – fyXPO – fission yeast
    
  • 3icq – fyXPO + GTP-binding nuclear protein + RNA
    
• XPO-5
  • 3a6p – hXPO + peptide + pre-microRNA