Ets1

Function Ets1 (E26 Transformation-Specific) is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation. Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. Relevance Ets1 promotes invasive behavior in endothelial cells, smooth muscle cells and epithelial cancer cells.

spinqualitylabelsall models Structure of mouse Ets1 ETS domain (green) complex with paired box protein Pax5 (grey) and MB-1 promoter DNA (PDB code 1mdm). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

3D Structures of Ets13D Structures of Ets1

Updated on 24-November-2014

{"openlevels":0}

• Ets1
  • 1md0 – mETS1 ETS domain - mouse
    
  • 1r36 – mETS1 ETS and autoinhibitory domains - NMR
    
  • 2jv3, 2kmd – mETS1 PNT domain - NMR
    
  • 1gvj – hETS1 ETS and autoinhibitory domains - human
    
• Ets1 binary complexes
  • 2nny – hETS1 + DNA
    
  • 3mfk – hETS1 + stromelysin promoter DNA
    
  • 3ri4 – hETS1 + TCR α promoter DNA
    
  • 2stt, 2stw – hETS1 + DNA - NMR
    
  • 1k79, 1k7a – mETS1 ETS domain + DNA containing GGAA - mouse
    
• Ets1 ternary complexes
  • 1mdm – mETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA
    
  • 1k78 – hETS1 ETS domain + paired box protein Pax5 + MB-1 promoter DNA - NMR
    
  • 4l0y, 4l0z, 4l18 – hETS1 + TCR α promoter DNA + RunT-related transcription factor
    
  • 4lg0 – hETS1 + cadherin promoter DNA + forkhead box protein