Dual specificity phosphatase

Dual specificity phosphatase (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:
• Slingshot phosphatase
• Phosphatase of regenerating liver
• Cdc14
• Cdc25
• PTEN
• Myotubularin
• MAPK phosphatase see MAP kinase phosphatase

3D structures of dual specificity phosphatase3D structures of dual specificity phosphatase

Updated on 24-November-2014

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• Slingshot phosphatase (SSH)
  • 2nt2 – hSSH-2L catalytic domain - human
    
• Phosphatase of regenerating liver (RPL)
  • 1xm2 – hPRL-1 (mutant)
    
  • 1zck, 1x24 – rPRL-1 - rat
    
  • 1zcl – rPRL-1 (mutant)
    
  • 1r6h, 1v3a, 2mbc – hPRL-3 - NMR
    
• Cdc14
  • 1ohc, 1ohd – hCdc14B2 core domain
    
  • 1ohe – hCdc14B2 core domain + peptide
    
• Cdc25
  • 1qb0, 1cwr, 1cws, 1cwt, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq – hCdc25B catalytic domain
    
  • 2a2k, 2ifd, 2ifv – hCdc25B catalytic domain (mutant)
    
• Phosphoinositide phosphatase PTEN
  • 1d5r – hPTEN (mutant)
    
• Myotubularin-related protein (MTMR)
  • 1zvr – hMTMR2 PH-gram and phosphatase domains (mutant)
    
  • 1zsq - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate
    
  • 1m7r, 1lw3 - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate
    
  • 2yf0 – hMTMR6
    
• MAPK phosphatase see MAP kinase phosphatase