egg lysinegg lysin

FunctionFunction

Egg Lysin, a protein from abalone sperm, creates a hole in the envelope of the egg, permitting the sperm to pass through the envelope and fuse with the egg.


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Structural highlightsStructural highlights

The structure of lysin, refined at 1.9 angstroms resolution, reveals an alpha-helical, amphipathic molecule. you can see the alpha helixes in pink. exhibits three features: two tracks of basic residues that span the length of the molecule, a solvent-exposed cluster of ,(in green) and an extended amino-terminal hypervariable domain that is species-specific. The structure suggests possible mechanisms of action.


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ReferencesReferences

The crystal structure of lysin, a fertilization protein. Shaw A1, McRee DE, Vacquier VD, Stout CD.

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Carmit Ginesin, Michal Harel, Jaime Prilusky, Alexander Berchansky, Joel L. Sussman