3ee8

Structure of NS1 effector domainStructure of NS1 effector domain

Structural highlights 3ee8 is a 2 chain structure with sequence from Viruses. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 3ee9 Gene: NS (Viruses) Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The nonstructural protein NS1A from influenza virus is a multifunctional virulence factor and a potent inhibitor of host immunity. It has two functional domains: an N-terminal 73-amino-acid RNA-binding domain and a C-terminal effector domain. Here, the crystallographic structure of the NS1A effector domain of influenza A/Udorn/72 virus is presented. Structure comparison with the NS1 effector domain from mouse-adapted influenza A/Puerto Rico/8/34 (PR8) virus strain reveals a similar monomer conformation but a different dimer interface. Further analysis and evaluation shows that the dimer interface observed in the structure of the PR8 NS1 effector domain is likely to be a crystallographic packing effect. A hypothetical model of the intact NS1 dimer is presented. Structure of NS1A effector domain from the influenza A/Udorn/72 virus.,Xia S, Monzingo AF, Robertus JD Acta Crystallogr D Biol Crystallogr. 2009 Jan;65(Pt 1):11-7. Epub 2008 Dec, 18. PMID:19153461 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

spinqualitylabelsall models 3ee8, resolution 2.60Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image