2px2
Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH (Monoclinic form 1)Crystal structure of the Murray Valley Encephalitis Virus NS5 2'-O Methyltransferase domain in complex with SAH (Monoclinic form 1)
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedWe have determined the high resolution crystal structure of the methyltransferase domain of the NS5 polypeptide from the Murray Valley encephalitis virus. This domain is unusual in having both the N7 and 2'-O methyltransferase activity required for Cap 1 synthesis. We have also determined structures for complexes of this domain with nucleotides and cap analogues providing information on cap binding, based on which we suggest a model of how the sequential methylation of the N7 and 2'-O groups of the cap may be coordinated. Crystal structure of the Murray Valley encephalitis virus NS5 methyltransferase domain in complex with cap analogues.,Assenberg R, Ren J, Verma A, Walter TS, Alderton D, Hurrelbrink RJ, Fuller SD, Bressanelli S, Owens RJ, Stuart DI, Grimes JM J Gen Virol. 2007 Aug;88(Pt 8):2228-36. PMID:17622627[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)
OCA- RNA-directed RNA polymerase
- Viruses
- Alderton, D.
- Assenberg, R.
- Fuller, S D.
- Grimes, J M.
- Hurrelbrink, R J.
- OPPF, Oxford Protein Production Facility.
- Owens, R J.
- Ren, J.
- Stuart, D I.
- Verma, A.
- Walter, T S.
- Methyltransferase
- Murray valley encephalitis virus
- Oppf
- Oxford protein production facility
- Sah
- Structural genomic
- Transferase