1hmc
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| , resolution 2.5Å | |||||||
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THREE-DIMENSIONAL STRUCTURE OF DIMERIC HUMAN RECOMBINANT MACROPHAGE COLONY STIMULATING FACTOR
OverviewOverview
Macrophage colony-stimulating factor (M-CSF) triggers the development of cells of the monocyte-macrophage lineage and has a variety of stimulatory effects on mature cells of this class. The biologically active form of M-CSF is a disulfide-linked dimer that activates an intrinsic tyrosine kinase activity on the M-CSF receptor by inducing dimerization of the receptor molecules. The structure of a recombinant human M-CSF dimer, determined at 2.5 angstroms by x-ray crystallography, contains two bundles of four alpha helices laid end-to-end, with an interchain disulfide bond. Individual monomers of M-CSF show a close structural similarity to the cytokines granulocyte-macrophage colony-stimulating factor and human growth hormone. Both of these cytokines are monomeric in their active form, and their specific receptors lack intrinsic tyrosine kinase activity. The similarity of these structures suggests that the receptor binding determinants for all three cytokines may be similar.
DiseaseDisease
Known disease associated with this structure: Myeloid malignancy, predisposition to OMIM:[164770]
About this StructureAbout this Structure
1HMC is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor., Pandit J, Bohm A, Jancarik J, Halenbeck R, Koths K, Kim SH, Science. 1992 Nov 20;258(5086):1358-62. PMID:1455231
Page seeded by OCA on Thu Mar 20 11:38:56 2008