1h8m

SOLUTION STRUCTURE OF YKT6

File:1h8m.gif

spinqualitylabelsall models PDB ID 1h8m Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image
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OverviewOverview

Ykt6p is a nonsyntaxin SNARE implicated in multiple intracellular membrane trafficking steps. Here we present the structure of the NH2-terminal domain of Ykt6p (Ykt6pN, residues 1 to 140). The structure of Ykt6pN differed entirely from that of syntaxin and resembled the overall fold of the actin regulatory protein, profilin. Like some syntaxins, Ykt6p adopted a folded back conformation in which Ykt6pN bound to its COOH-terminal core domain. The NH2-terminal domain plays an important biological role in the function of Ykt6p, which in vitro studies revealed to include influencing the kinetics and proper assembly of SNARE complexes.

About this StructureAbout this Structure

1H8M is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

ReferenceReference

An autoinhibitory mechanism for nonsyntaxin SNARE proteins revealed by the structure of Ykt6p., Tochio H, Tsui MM, Banfield DK, Zhang M, Science. 2001 Jul 27;293(5530):698-702. PMID:11474112

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