1lkf

LEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUSLEUKOCIDIN F (HLGB) FROM STAPHYLOCOCCUS AUREUS

Structural highlights 1lkf is a 1 chain structure with sequence from Staphylococcus aureus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Gene: LUKF (Staphylococcus aureus) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed Staphylococcal LukF, LukS, HgammaII, and alpha-hemolysin are self-assembling, channel-forming proteins related in sequence and function. In the alpha-hemolysin heptamer, the channel-forming beta-strands and the amino latch make long excursions from the protomer core. Here we report the crystal structure of the water soluble form of LukF. In the LukF structure the channel-forming region folds into an amphipathic, three-strand beta-sheet and the amino latch forms a beta-strand extending a central beta-sheet. The LukF structure illustrates how a channel-forming toxin masks protein-protein and protein-membrane interfaces prior to cell binding and assembly, and together with the alpha-hemolysin heptamer structure, they define the end points on the pathway of toxin assembly. Crystal structure of staphylococcal LukF delineates conformational changes accompanying formation of a transmembrane channel.,Olson R, Nariya H, Yokota K, Kamio Y, Gouaux E Nat Struct Biol. 1999 Feb;6(2):134-40. PMID:10048924 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Pore forming toxin%2C α-hemolysin

spinqualitylabelsall models 1lkf, resolution 1.90Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image