1if1

INTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNAINTERFERON REGULATORY FACTOR 1 (IRF-1) COMPLEX WITH DNA

Structural highlights 1if1 is a 4 chain structure with sequence from Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The family of interferon regulatory factor (IRF) transcription factors is important in the regulation of interferons in response to infection by virus and in the regulation of interferon-inducible genes. The IRF family is characterized by a unique 'tryptophan cluster' DNA-binding region. Here we report the crystal structure of the IRF-1 region bound to the natural positive regulatory domain I (PRD I) DNA element from the interferon-beta promoter. The structure provides the first three-dimensional view of a member of the growing IRF family, revealing a new helix-turn-helix motif that latches onto DNA through three of the five conserved tryptophans. The motif selects a short GAAA core sequence through an obliquely angled recognition helix, with an accompanying bending of the DNA axis in the direction of the protein. Together, these features suggest a basis for the occurrence of GAAA repeats within IRF response elements and provide clues to the assembly of the higher-order interferon-beta enhancesome. Structure of IRF-1 with bound DNA reveals determinants of interferon regulation.,Escalante CR, Yie J, Thanos D, Aggarwal AK Nature. 1998 Jan 1;391(6662):103-6. PMID:9422515 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Interferon regulatory factor

spinqualitylabelsall models 1if1, resolution 3.00Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image