2j0t

File:2j0t.gif

spinqualitylabelsall models 2j0t, resolution 2.54Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF MMP-1 IN COMPLEX WITH THE INHIBITORY DOMAIN OF TIMP-1

OverviewOverview

The mammalian collagenases are a subgroup of the matrix metalloproteinases, (MMPs) that are uniquely able to cleave triple helical fibrillar, collagens. Collagen breakdown is an essential part of extracellular matrix, turnover in key physiological processes including morphogenesis and wound, healing; however, unregulated collagenolysis is linked to important, diseases such as arthritis and cancer. The tissue inhibitors of, metalloproteinases (TIMPs) function in controlling the activity of MMPs, including collagenases. We report here the structure of a complex of the, catalytic domain of fibroblast collagenase (MMP-1) with the N-terminal, inhibitory domain of human TIMP-1 (N-TIMP-1) at 2.54 A resolution., Comparison with the previously reported structure of the, TIMP-1/stromelysin-1 ... [(full description)]

About this StructureAbout this Structure

2J0T is a [Protein complex] structure of sequences from [Homo sapiens] with ZN and CA as [ligands]. Active as [Interstitial collagenase], with EC number [3.4.24.7]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].

ReferenceReference

Crystal structure of the catalytic domain of matrix metalloproteinase-1 in complex with the inhibitory domain of tissue inhibitor of metalloproteinase-1., Iyer S, Wei S, Brew K, Acharya KR, J Biol Chem. 2007 Jan 5;282(1):364-71. Epub 2006 Oct 18. PMID:17050530

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