2hth

Structural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domainStructural basis for ubiquitin recognition by the human EAP45/ESCRT-II GLUE domain

Structural highlights 2hth is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Related: 2cay Gene: RPS27A, UBA52, UBB, UBC (Homo sapiens), VPS36, C13orf9, EAP45 (Homo sapiens) Resources: FirstGlance, OCA, RCSB, PDBsum Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMed The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting. Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.,Alam SL, Langelier C, Whitby FG, Koirala S, Robinson H, Hill CP, Sundquist WI Nat Struct Mol Biol. 2006 Nov;13(11):1029-30. Epub 2006 Oct 22. PMID:17057716 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Ubiquitin

spinqualitylabelsall models 2hth, resolution 2.70Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image