Tubulin

Tubulin (TUB) is a constituent of microtubules in eukaryotes. Microtubules are assembled from dimers of α-tubulin (TUBA) and β-tubulin (TUBB) bound to GTP. γ-tubulin (TUBG) is part of the nucleation of microtubules. Human TUB contains several numbered subtypes. FtsZ (Filamenting temperature-sensitive mutant Z) is a prokaryotic homologue of TUB.

3D Structures of Tubulin3D Structures of Tubulin

Updated on 28-September-2014

α-tubulinα-tubulin

2bto – PdTUBA+thioredoxin 1 – Prosthecobacter dejongeii
2e4h – hTUBA C terminal + restin CAP-Gly domain 2 – human

α-tubulin + β-tubulinα-tubulin + β-tubulin

3hkb, 3hkc, 3hkd, 3hke, 3n2g, 3n2k, 3ryc, 3ryf, 3ryh, 3ryi – sTUBA+sTUBB+stathmin-like protein B3 – sheep
4f61 - sTUBA+sTUBB+stathmin-like protein R4
3ut5 - sTUBA+sTUBB+stathmin-like protein B3 + vinca peptide
4eb6 - sTUBA+sTUBB+stathmin-4
4drx - sTUBA+sTUBB + ankyrin repeat protein
4f6r - sTUBA+sTUBB+stathmin-like protein R1 + ankyrin repeat protein
2wbe – bTUBA1D+bTUBB2B+kinesin+AMPPNP – bovine
3dco - bTUBA+bTUBB+kinesin-like NOD
4ck5, 4kc6, 4kc7 - bTUBA+bTUBB+kinesin-like KIF11 motor domain
1tvk - bTUBA+bTUBB+GDP+GTP+Epothilone A – electron crystallography
3iz0 - bTUBA+bTUBB+hNDC80/SPC25+hNUF2/SPC24 – electron microscopy
3edl - bTUBA1D+bTUBB2B+kinesin motor domain
2xrp - bTUBA1D+bTUBB2B+doublecortin
3du7, 3e22, 1z2b, 1sa0, 1sa1 – bTUBA1C+bTUBB2B+stathmin-like protein B3
1ffx - bTUBA+bTUBB+stathmin-like protein B3
4o2a - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase
4o2b - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + colchicine
4o4h - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + laulimalide
4o4i - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + epothilone + laulimalide
4o4j - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + peloruside
4o4l - bTUBA+bTUBB+stathmin-like protein B3 + TUB-Tyr ligase + peloruside + epothilone
1jff - bTUBA+bTUBB
4hna - bTUBA+bTUBB + kinesin heavy chain + ankyrin repeat protein
4ihj - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase + ADP
4iij, 4i55 - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase
3j1t, 3j1u - bTUBA+bTUBB+ dyenin
3j2u - bTUBA+bTUBB+kinesin-like KLP10A head domain
4i50, 4i4t - bTUBA+bTUBB+stathmin-like protein B3 + tubulin tyrosine ligase + anti-cancer agent
2p4n - hTUBA+hTUBB+kinesin heavy chain
2hxf - pTUBA+pTUBB+kinesin-like KIF1A+AMPPNP – pig
2hxh - pTUBA+pTUBB+kinesin-like KIF1A+ADP
1ia0 - pTUBA+pTUBB+kinesin-like KIF1A+ATP
4abo - pTUBA+pTUBB+ microtubule integrity protein MAL3
1tub - pTUBA+pTUBB – electron diffraction
4aqv, 4aqw - bTUBA+bTUBB+kinesin-like KIF11 – Cryo EM
4atu - bTUBA1D+bTUBB2B+doublecortin – Cryo EM
4atx - bTUBA1D+bTUBB2B+kinesin motor domain – Cryo EM
2btq – PdTUBA+PdTUBB
4ffb - TUBA+TUBB (mutant) + protein STU2 - yeast

γ-tubulinγ-tubulin

3cb2 – hTUBG1+GDP
1z5v - hTUBG1+GTPgS
1z5w - hTUBG1+GTP
3rip – hTUBG4

FtsZFtsZ

2vxy, 2vam – BsFtsZ - Bacillus subtilis
2ve8 – PaFtsZ gamma domain – Pseudomonas aeruginosa
2r6r– AaFtsZ - Aquifex aeolicus
1w59, 1fsz – MjFtsZ - Methancaldococcus jannaschii
1w5e, 1w5f – MjFtsZ (mutant)
3v3t – FtsZ (mutant) – Clostridium botulinum
3zid – FtsZ – Methanosaeta thermophila
3vo9, 3vpa - SaFtsZ – Staphylococcus aureus
3wgj, 3wgk – SaFtsZ (mutant)

FtsZ complexesFtsZ complexes

2rhh, 2rhj – BsFtsZ+SO4
2rhl - BsFtsZ+GDP
2rho - BsFtsZ+GDP+GTP-gamma-S
2ve9 - PaFtsZ gamma domain+DNA
2vaw – PaFtsZ+GDP
1ofu - PaFtsZ+SULA
2r75 - AaFtsZ+8-morpholino-GTP
2q1x, 1rq2 - MtFtsZ+citrate – Mycobacterium tuberculosis
2q1y, 1rlu - MtFtsZ+GTP-gamma-S
1rq7, 4kwe - MtFtsZ+GDP
2vap – MjFtsZ+GDP
1w58 - MjFtsZ+GMPCPP
1w5a - MjFtsZ+MgGTP
1w5b - MjFtsZ+GTP
4b45 – HvFtsZ + GTP-γS – Haloferax volcanii
3vo8, 3voa - SaFtsZ + GDP
3wgl – SaFtsZ (mutant) + GDP
3wgn – SaFtsZ + GTP-γS
3wgm – SaFtsZ (mutant) + GTP
3vob - SaFtsZ + GDP + benzamide derivative
4dxd - SaFtsZ + antibiotic
4b46 - HvFtsZ + GDP
4m8i - SeFtsZ + GDP – Staphylococcus epidermitis