Survivin

<StructureSection load='3uig' size='340' side='right' caption='Structure of human survivin dimer (grey and green) complex with histone H3 peptide (cyan) and Zn+2 ion (grey) (PDB code 3uig).' scene=>

FunctionFunction

Survivin or apoptosis inhibitor 4 (IAP4) plays a dual role. It inhibits caspase activation and thus it inhibits apoptosis and promotes cell proliferation.

DiseaseDisease

IAP4 is found in human cancer cells and can serve as a cancer marker and as a target for chemotherapy.

3D structures of survivin3D structures of survivin

Updated on 24-September-2014

SurvivinSurvivin

1e31 – hIAP4 – human
1f3h, 3ueg, 3ueh, 3uei – hIAP4 (mutant)
1xox – hIAP4 – NMR
1m4m – IAP4 – mouse

Survivin complexSurvivin complex

2raw, 2rax – hIAP4 + Borealin N-terminal
2qfa – hIAP4 + Borealin N-terminal + inner centromere protein
4a0i – hIAP4 + shugoshin peptide
4a0j, 4a0n, 3uig, 3uii, 3ued – hIAP4 + histone H3 peptide
3uik, 3uec, 3uee, 3uef – hIAP4 (mutant) + histone H3 peptide
3uih – hIAP4 + diablo peptide
3uij – hIAP4 (mutant) + diablo peptide