Growth factor receptor-bound protein
<StructureSection load='1tze' size='350' side='right' caption='Structure of human Grb2 SH2 domain (pink) complex with phosphotyrosyl heptapeptide (gold) (PDB entry 1tze)' scene=>
Growth factor receptor-bound proteins (GRB) are adaptor proteins. GRBs contain SH2, Ras-associated (RA) and pleckstrin homology (PH) domains.
- GRB2 links the epidermal growth factor receptor tyrosine kinase to the activation of Ras and its downstream kinases. GRB2 contains an SH2 domain which binds tyrosine phosphorylated sequences and 2 SH3 domains which direct complex formation of proline-rich sequences. GRB2 is involved in signal transduction.
- GRB7 interacts with EGFR and ephrin receptors and plays a role in itegrin signalling pathway.
- GRB10 interacts with insulin receptor and insulin-like growth factor receptors. For additional details on GRB10 see Grb10 SH2 Domain.
3D structures of Grb3D structures of Grb
Updated on 27-August-2014
GRB2GRB2
GRB2 C terminal SH3 domain
1gfc, 1gfd – hGRB2 C terminal SH3 domain - NMR
2vvk, 2vwf, 2w0z – hGRB2 C terminal SH3 domain
1io6 – hGRB2 C terminal SH3 domain + ligand peptide - NMR
1gcq – hGRB2 C terminal SH3 domain + VAV proto-oncogene SH3 domain
GRB2 N terminal SH3 domain
1gbr, 1gbq, 2gbq, 3gbq, 4gbq – mGRB2 N terminal SH3 domain + Sos-A peptide – mouse - NMR
1aze – mGRB2 N terminal SH3 domain + Sos-A peptide - NMR
GRB2 SH2 domain
1jyu – hGRB2 SH2 domain
1ghu – hGRB2 SH2 domain (mutant) - NMR
1fhs – hGRB2 SH2 domain - NMR
1x0n – hGRB2 SH2 domain + inhibitor - NMR
2huw – hGRB2 SH2 domain + cyclopropane derivative
1cj1 – hGRB2 SH2 domain + phosphor-Tyr derivative
2aoa, 2aob – hGRB2 SH2 domain + peptide mimetic
1tze, 1bmb, 1bm2, 1zfp, 1fyr, 1jyq, 1jyr, 2h5k, 3c7i, 3imd, 3imj, 3in7, 3in8, 3kfj, 3n8m, 3n7y, 3n84, 3mxc, 3mxy, 3ov1, 3ove, 3s8l, 3s8n, 3s8o, 1zfp – hGRB2 SH2 domain + phosphor-Tyr peptide
1qg1 – hGRB2 SH2 domain + phosphor-Tyr peptide - NMR
3wa4 - hGRB2 SH2 domain + CD28 peptide
GRB4GRB4
4e6r – hGRB4 C terminal SH3 domain
GRB7GRB7
2qms – hGRB7 SH2 domain
1mw4, 2l4k – hGRB7 SH2 domain + phosphor-Tyr peptide - NMR
3pqz – hGRB7 SH2 domain + cyclic peptide
1wgr – hGRB7 RA domain - NMR
GRB10GRB10
1nrv – hGRB10 SH2 domain
3m7f – hGRB10 SH2 domain + NEDD4 C2 domain
3hk0 – hGRB10 RA and PH domains
GRB14GRB14
2aug – hGRB14 SH2 domain
2auh – hGRB14 BPS domain + insulin receptor kinase domain
4k81 – hGRB14 RA and PH domains + GTPase Hras