RmlC

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RmlC is an enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human.

RelevanceRelevance

Inhibitors of RmlC can serve as potential antimicrobial drugs.

3D structures of RmlC3D structures of RmlC

Updated on 21-August-2014

RmlCRmlC

1pm7, 1upi – MtRmlC – Mycobacterium tuberculosis
2ixj, 1rtv – PaRmlC – Pseudomonas aeruginosa
1nxm – SsRmlC – Streptococcus suis
1ep0 – MetRmlC – Methanothermobacter thermautotrophicus
1dzr – StRmlC – Salmonella typhimurium

RmlC complexesRmlC complexes

2ixc – MtRmlC + dTDP rhamnose
2ixh – PaRmlC + dTDP rhamnose
2ixl – SsRmlC + dTDP rhamnose
2ixk – PaRmlC + dTDP-keto rhamnose
1nyw – SsRmlC + dTDP glucose
1nzc – SsRmlC + dTDP xylose
1epz – MetRmlC + TDP
3ryk – RmlC + TDP + pyrophosphate – Bacillus anthracis
1dzt – StRmlC + acetylthymidine diphosphate