Neurexin

Neurexins (NRXN) are a family of presynaptic proteins which bind to the postsynaptic Neuroligin (NLGN) to form a complex which attaches neurons. The NRXN family contains 4 members which are numbered 1 to 4. The NRXN-α contains 6 homologous LNS domains while the NRXN-β contains only LNS6. See Neurodevelopmental Disorders.

For Structural Analysis of Neurexin, See: Neuroligin-Neurexin Interaction

3D Structures of Neurexin3D Structures of Neurexin

Updated February 2013

NRXNNRXN

3mw2 – mNRXN-1α LNS domain+splice insert 4 – mouse
3bod, 3bop - mNRXN-1α LNS domain
3mw3, 2r1b - rNRXN-1α LNS domain+splice insert 4 – rat
2r16 - rNRXN-1α LNS domain+Ca
1c4r - rNRXN-1α LNS domain
3mw4 - mNRXN-1α LNS domain
2h0b - bNRXN-1α LNS2 domain – bovine
3asi - bNRXN-1α LNS5-EGF3-LNS6 domains
3poy - bNRXN-1α LNS2-LNS6 domains (mutant)
3qcw, 3r05 - bNRXN-1α LNS1-LNS6 domains (mutant)
2r1d - rNRXN-1β LNS/LG domain

NRXN+NLGNNRXN+NLGN

2xb6, 2wqz – rNRXN-1α LNS domain +hNLGN-4 cholinesterase domain
3b3q - hNRXN-1α LNS domain+mNLGN-4 cholinesterase domain
3biw - rNRXN-1α LNS domain+rNLGN-1 cholinesterase domain
3vkf - bNRXN-1β LNS domain+rNLGN-1 cholinesterase domain