Glucocorticoid receptor

Template:STRUCTURE 3g6r Glucocorticoid receptor (GCR) is the nuclear receptor binding cortisol and glucocorticoids. GCR regulates genes involved in development, metabolism and immune response. The glucocorticoid-bound GCR can either up-regulate the expression of anti-inflammatory proteins (transactivation) or repress the expression of pro-inflammatory proteins (transrepression). GCR contains 5 domains: N terminal regulatory domain; DNA-binding domain (DBD); hinge region; ligand-binding domain (LBD) and C terminal domain. GCR interacts with nuclear receptor coactivator 2 (NCOA2) which promotes DNA transcription by acylating histones.

3D structures of glucocorticoid receptor3D structures of glucocorticoid receptor

Updated on 18-August-2014

Glucocorticoid receptor DBD domainGlucocorticoid receptor DBD domain

1gdc, 2gda, 1rgd – rGCR DBD – NMR – rat
3g9p, 3fyl, 3g6p, 3g6q, 3g6r, 3g6t, 3g6u, 3g8u, 3g8x, 3g97, 3g99, 3g9i, 3g9m, 3g9j, 3g9o, 1glu, 1lat, 1r4o, 1r4r - rGCR DBD + DNA
4hn5, 4hn6 - hGCR DBD + DNA – human

Glucocorticoid receptor LBD domainGlucocorticoid receptor LBD domain

1m2z, 3cld, 3bqd, 4lsj - hGCR LBD (mutant) + NCOA2 peptide + steroid
3e7c - hGCR LBD (mutant) + NCOA2 peptide + non-steroid
al agonist 3k23 - hGCR LBD (mutant) + NCOA2 peptide + prolinamide
3k22 - hGCR LBD (mutant) + transcriptional intermediary factor 2 peptide + alaninamide
3h52 - hGCR LBD (mutant) + NCOA1 peptide + steroid
3gn8 - hGCR LBD + NCOA2 peptide + steroid
3ry9 - GCR LBD ancestral + steroid
4e2j - GCR LBD ancestral + NCOA2 peptide + steroid
3mne, 3mno, 3mnp - GCR LBD (mutant) + NCOA2 peptide + steroid
– mouse

Glucocorticoid receptor LBD+hinge domainsGlucocorticoid receptor LBD+hinge domains

1nhz – hGCR LBD+hinge (mutant) + steroid
1p93 - hGCR LBD+hinge (mutant) + NCOA2 peptide + steroid