2cfe
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THE 1.5 A CRYSTAL STRUCTURE OF THE MALASSEZIA SYMPODIALIS MALA S 6 ALLERGEN, A MEMBER OF THE CYCLOPHILIN PAN-ALLERGEN FAMILY
OverviewOverview
Cyclophilins constitute a family of proteins involved in many essential, cellular functions. They have also been identified as a panallergen family, able to elicit IgE-mediated hypersensitivity reactions. Moreover, it has, been shown that human cyclophilins are recognized by serum IgE from, patients sensitized to environmental cyclophilins. IgE-mediated, autoreactivity to self-antigens that have similarity to environmental, allergens is often observed in atopic disorders. Therefore comparison of, the crystal structure of human proteins with similarity to allergens, should allow the identification of structural similarities to rationally, explain autoreactivity. A new cyclophilin from Aspergillus fumigatus (Asp, f 27) has been cloned, expressed and showed to exhibit cross-reactivity in, ... [(full description)]
About this StructureAbout this Structure
2CFE is a [Single protein] structure of sequence from [Malassezia sympodialis] with ALA and GOL as [ligands]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Analysis of the cross-reactivity and of the 1.5 A crystal structure of the Malassezia sympodialis Mala s 6 allergen, a member of the cyclophilin pan-allergen family., Glaser AG, Limacher A, Fluckiger S, Scheynius A, Scapozza L, Crameri R, Biochem J. 2006 May 15;396(1):41-9. PMID:16483252
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