Diphtheria toxin

<StructureSection load='1tox' size='340' side='right' caption='Structure of diphtheria toxin complex with NAD (PDB code 1tox).' scene=>

FunctionFunction

Diphtheria toxin (DT) is a toxin which is secreted by the bacteria causing diphtheria. DT contains 2 subunits. Subunit A contains the catalytic domain and subunit B contains the transmembrane and receptor-binding domains. DT catalyzes the transfer of NAD to a diphthamide residue in the elongatin factor-2 and thus inhibiting protein synthesis.

DiseaseDisease

A lethal dose of DT is ca. 0.1 μg per 1 kg of bodyweight.

3D structures of diphtheria toxin3D structures of diphtheria toxin

Updated on 24-June-2014

1sgk, 4ow6 – CbDT – Corynebacterium diphtheriae
4ae0 – CdDT (mutant)

Diphtheria toxin complexDiphtheria toxin complex

1ddt, 1mdt, 1f0l – CdDT + adenylyl phosphor-UMP
1tox – CdDT + NAD
4ae1 – CdDT (mutant) + nicotinamide
1xdt – CdDT + heparin-binding epidermal growth factor
1dtp – CdDT catalytic domain + adenylyl phosphor-UMP