Dual specificity phosphatase

Dual specificity phosphatase (DUSP) is a phosphatase which acts on tyrosine, serine or threonine residues. There are several DUSP enzymes in mammals sharing a common catalytic mechanism. The DUSP include:
• Slingshot phosphatase
• Phosphatase of regenerating liver
• Cdc14
• Cdc25
• PTEN
• Myotubularin
• MAPK phosphatase see MAP kinase phosphatase

3D structures of dual specificity phosphatase3D structures of dual specificity phosphatase

Updated on 19-June-2014

slingshot phosphatase (SSH)slingshot phosphatase (SSH)

2nt2 – hSSH-2L catalytic domain - human

Phosphatase of regenerating liver (RPL)Phosphatase of regenerating liver (RPL)

1xm2 – hPRL-1 (mutant)
1zck, 1x24 – rPRL-1 - rat
1zcl – rPRL-1 (mutant)
1r6h, 1v3a, 2mbc – hPRL-3 - NMR

Cdc14Cdc14

1ohc, 1ohd – hCdc14B2 core domain
1ohe – hCdc14B2 core domain + peptide

Cdc25Cdc25

1qb0, 1cwr, 1cws, 1cwt, 1ym9, 1ymd, 1ymk, 1yml, 1ys0, 2uzq – hCdc25B catalytic domain
2a2k, 2ifd, 2ifv – hCdc25B catalytic domain (mutant)

Phosphoinositide phosphatase PTENPhosphoinositide phosphatase PTEN

1d5r – hPTEN (mutant)

Myotubularin-related protein (MTMR)Myotubularin-related protein (MTMR)

1zvr – hMTMR2 PH-gram and phosphatase domains (mutant)
1zsq - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphatidylinositol 3-phosphate
1m7r, 1lw3 - hMTMR2 PH-gram and phosphatase domains (mutant) + phosphate
2yf0 – hMTMR6

MAPK phosphataseMAPK phosphatase

MAP kinase phosphatase