1c3t
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ROTAMER STRAIN AS A DETERMINANT OF PROTEIN STRUCTURAL SPECIFICITY
OverviewOverview
We present direct evidence for a change in protein structural specificity due to hydrophobic core packing. High resolution structural analysis of a designed core variant of ubiquitin reveals that the protein is in slow exchange between two conformations. Examination of side-chain rotamers indicates that this dynamic response and the lower stability of the protein are coupled to greater strain and mobility in the core. The results suggest that manipulating the level of side-chain strain may be one way of fine tuning the stability and specificity of proteins.
DiseaseDisease
Known disease associated with this structure: Cleft palate, isolated OMIM:[191339]
About this StructureAbout this Structure
1C3T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
ReferenceReference
Rotamer strain as a determinant of protein structural specificity., Lazar GA, Johnson EC, Desjarlais JR, Handel TM, Protein Sci. 1999 Dec;8(12):2598-610. PMID:10631975
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