Ribonucleotide reductase

Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR. Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction. Class II RNR reduces ribonucleotide triphosphates using coenzyme B12. Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center. For details on human RNR2 see P53R2. For mouse RNR see Mouse Ribonucleotide Reductase R2.

3D Structures of Ribonucleotide reductase3D Structures of Ribonucleotide reductase

Updated on 11-June-2014

Class I RNRClass I RNR

RNR large subunitRNR large subunit

1zyz, 1zzd, 2cvs, 2cvt, 2cvu, 2cvv, 2cvw, 2cvx, 2cvy - yRNR R1 – yeast
5r1r, 6r1r, 7r1r, 1r1r, 1rlr, 1mrr - EcRNR R1 – Escherichia coli
4n82 – SsRNR – Streptococcus sanguinis

RNR large subunit complexRNR large subunit complex

3hnc – hRNR M1 + TTP – human
3hnd – hRNR M1 + GDP + TTP
3hne, 3hnf – hRNR M1 + ATP + TTP
2wgh - hRNR M1 + ATP + Mg
3paw - yRNR R1 + ATP
3k8t - yRNR R1 + ADP analog
3s87 - yRNR R1 + ADP + GTP
3s8a - yRNR R1 (mutant) + GTP
3tba - yRNR R1 (mutant) + GTP + ADP
3s8b - yRNR R1 + AMPPNP + CDP
3s8c, 3tb9 - yRNR R1 (mutant) + AMPPNP + CDP
2zlf, 2zlg - yRNR R1 + peptide
2eud - yRNR R1 + ligand
3rsr – yRNR + inhibitor
2r1r - EcRNR R1 + TTP
3r1r - EcRNR R1 + AMPPNP
4r1r - EcRNR R1 + GDP + TTP
1qfn - EcRNR R1 + glutaredoxin 1
1peu - StRNR + DTP - Salmonella typhimurium

RNR small subunitRNR small subunit

2xof, 3n37, 3n38, 2alx, 1piy, 1r65, 1mxr, 1jqc, 1jpr, 1av8, 1xik, 1rib, 4m1f – EcRNR R2
1yfd, 1piz, 1pj0, 1pj1, 1pm2, 1pim, 1piu, 1biq, 2av8, 1pfr - EcRNR R2 (mutant)
3hf1, 2vux, 2uw2, 4djn – hRNR M2
3mjo, 3dhz, 1oqu, 1kgn, 1kgo, 1kgp – RNR R2 – Corynebacterium ammoniagenes
2p1i – RNR R2 – Plasmodium yoelii
2o1z - RNR R2 – Plasmodium vivax
1w68, 1h0n, 1h0o, 1xsm – mRNR R2 – mouse
1smq, 1sms – yRNR 2
4d8f, 4d8g, 4m1i - CtRNR R2 + Fe + Mn
1syy - CtRNR R2 + Fe + Pb– Chlamydia trachomatis
2ani - CtRNR R2 (mutant) + Fe + Pb
4m1h - CtRNR R2
4dr0 - RNR + Mn – Bacillus subtilis
1uzr – RNR R2 – Mycobacterium tuberculosis
3olj – hRNR M2
1jk0 – yRNR Y2+Y4
3vpm, 3vpn, 3vpo – hRNR M2 (mutant)
2rcc – RNR – Bacillus halodurans
4bmq, 4bmr, 4bmt - BcRNR + Fe – Bacillus cereus
4bmu - BcRNR + Mn
4n83 - SsRNR + Mn

RNR small subunit complexRNR small subunit complex

1rsr, 1rsv - EcRNR R2 (mutant) + N3
3n39, 3n3a, 3n3b – EcRNR R2 + NrdI
1rnr – EcRNR R2 (mutant) + dopa
1w69 – mRNR R2 + acetate
4bmo, 4bmp - BcRNR + NRDI

RNR small+large subunitRNR small+large subunit

3uus, 4erm - EcRNR R1+ R2
4erp - EcRNR R1+ R2 + inhibitor
2xak, 2xap, 2xo4, 2xo5 - EcRNR R1+ R2 peptide
2xav, 2xaw, 2xax, 2xay, 2xaz, 2x0x - EcRNR R1 (mutant) + R2 peptide
2bq1 - StRNR R1+ R2

Class II RNRClass II RNR

1xjf – TmRNR + ATP – Thermotoga maritima
1xjg - TmRNR + ATP-UDP
1xjj - TmRNR + GTP
1xjk - TmRNR + GTP-ADP
1xjm - TmRNR + TTP
1xje - TmRNR + TTP-GDP
1xjn - TmRNR + ATP-CDP
3o0n - TmRNR + TTP + Co + Mg + deoxyadenosine + B12
3o0o - TmRNR + TTP + GDP + Mg + deoxyadenosine + B12
3o0q - TmRNR + TTP + GDP + Mg + adenosine
1pem - StRNR R1
1r2f, 2r2f - StRNR R2
1peo, 1peq, 2peu - StRNR R1 + effector
1l1l – RNR (mutant) – Lactobacillus leichmannii

Class III RNRClass III RNR

1h78, 1h79, 1h7a, 1hk8 – T4RNR (mutant) + nucleotide triphosphate – bacteriophage T4
1h7b – T4RNR (mutant)