14-3-3 protein

<StructureSection load='4dhp' size='340' side='right' caption='Structure of human 14-3-3 protein σ complex with TASK-3 peptide and stabilizer (PDB code 4dhp).' scene=>

FunctionFunction

14-3-3 proteins (PRS) are conserved regulatory proteins which bind to a multitude of signaling proteins like kinases phosphatases and transmembrane receptors. The name 14-3-3 derives from their elution pattern via chromatography.

DiseaseDisease

Elevated levels of PRS are found in patients with Creutzfeld-Jakob disease.

3D structures of 14-3-3 proteins3D structures of 14-3-3 proteins

Updated on 10-June-2014

14-3-3 protein σ

1yz5 – hPRS – human

14-3-3 protein σ binary complex with peptide

1ywt – hPRS + phosphopeptide
3lw1 – hPRS + p53 peptide
3iqj, 3iqu, 4iea – hPRS + Raf-1 peptide
3mhr – hPRS + YAP peptide
3p1n – hPRS + TASK-3 peptide
3p1p, 3p1r – hPRS (mutant) + TASK-3 peptide
4dat, 4dau – hPRS + PADI6 peptide
4jc3, 4jdd – hPRS + estrogen receptor peptide
4fl5 – hPRS + τ protein peptide

14-3-3 protein σ binary complex with small molecule

3u9x – hPRS + pyridoxal phosphate
3t0l, 3t0m, 4dhm, 4dhn, 4dho, 4dhp, 4dhq, 4dhr, 4dhs, 4dht, 4dhu – hPRS + inhibitor
4hqw, 4hru – hPRS + molecular tweezers

14-3-3 protein σ ternary complex with stabilizer

3p1o, 3ux0, 4fr3 – hPRS + TASK-3 peptide + stabilizer
3p1q, 3p1s, 3spr, 3smk, 3sml, 3smm, 3smn, 3smo – hPRS (mutant) + TASK-3 peptide + stabilizer
3iqv, 3o8i – hPRS + Raf-1 peptide + stabilizer

14-3-3 protein ζ

1a4o – bPRS - bovine
1a37 – bPRS + Raf peptide
1a38 – bPRS + R18 peptide

14-3-3 protein ζ/δ

3rdh – hPRS
1qja, 1qjb – hPRS + phosphopeptide
2c1j, 2c1n – hPRS + histone H3 peptide
2o02, 4n7g, 4n7y, 4n84 – hPRS + exoenzyme S peptide
2v7d, 4hkc – hPRS + integrin peptide
3cu8, 3nkx, 4fj3, 4ihl – hPRS + Raf-1 peptide
2wh0 – hPRS + protein kinase C ε peptide
4bg6 – hPRS + RND3 peptide
1ib1 – hPRS + serotonin N-acetyltransferase

14-3-3 protein γ

4e2e – hPRS
2b05 – hPRS + phosphopeptide
3uzd – hPRS + histone deacylase peptide
4j6s – hPRS + tyrosine hydroxylase peptide
4o46 – hPRS + influenza C-terminal peptide

14-3-3 protein β/α

2bq0, 2dnk – hPRS
2c23 – hPRS + exoenzyme S peptide
4gnt – PRS + CHREBP peptide - mouse

14-3-3 protein θ

2btp – hPRS + phosphopeptide

14-3-3 protein η

2c63, 2c74 – hPRS + phosphopeptide

14-3-3 protein ε

2br9 – hPRS + phosphopeptide
3ual, 3ubw – hPRS + myeloid leukemia factor 1 peptide