2c82
X-RAY STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE, DXR, RV2870C, FROM MYCOBACTERIUM TUBERCULOSIS
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OverviewOverview
1-deoxy-D-xylulose 5-phosphate reductoisomerase catalyzes the, NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose, 5-phosphate to form 2-C-methyl-D-erythritol 4-phosphate, as the second, step of the deoxyxylulose 5-phosphate/methylerythritol 4-phosphate pathway, found in many bacteria and plants. The end product, isopentenyl, diphosphate, is the precursor of various isoprenoids vital to all living, organisms. The pathway is not found in humans; the mevalonate pathway is, instead used for the formation of isopentenyl diphosphate. This, difference, combined with its essentiality, makes the reductoisomerase an, excellent drug target in a number of pathogenic organisms. The structure, of 1-deoxy-D-xylulose 5-phosphate reductoisomerase from Mycobacterium, tuberculosis (Rv2870c) ... [(full description)]
About this StructureAbout this Structure
2C82 is a [Single protein] structure of sequence from [Mycobacterium tuberculosis] with SO4 as [ligand]. Active as [1-deoxy-D-xylulose-5-phosphate reductoisomerase], with EC number [1.1.1.267]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
The 1.9 A resolution structure of Mycobacterium tuberculosis 1-deoxy-D-xylulose 5-phosphate reductoisomerase, a potential drug target., Henriksson LM, Bjorkelid C, Mowbray SL, Unge T, Acta Crystallogr D Biol Crystallogr. 2006 Jul;62(Pt 7):807-13. Epub 2006, Jun 20. PMID:16790937
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