3zrk

Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitorsIdentification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors

Structural highlights 3zrk is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance. Ligands: , , NonStd Res: Related: 2uw9, 1o6k, 1gng, 1h8f, 1q3w, 1i09, 1o9u, 2x37, 1o6l, 2jdr, 1j1b, 1r0e, 2x39, 1q41, 1q3d, 2jld, 1q5k, 2jdo, 1pyx, 1q4l, 1j1c, 2xh5, 1uv5, 3zrm, 3zrl Activity: [Tau_protein_kinase [Tau protein] kinase], with EC number 2.7.11.26 Resources: FirstGlance, OCA, RCSB, PDBsum Publication Abstract from PubMed The discovery of a novel series of 2-(4-pyridyl)thienopyridinone GSK-3beta inhibitors is reported. X-ray crystallography reveals its binding mode and enables rationalization of the SAR. The initial optimization of the template for improved cellular activity and predicted CNS penetration is also presented. Identification of 2-(4-pyridyl)thienopyridinones as GSK-3beta inhibitors.,Gentile G, Bernasconi G, Pozzan A, Merlo G, Marzorati P, Bamborough P, Bax B, Bridges A, Brough C, Carter P, Cutler G, Neu M, Takada M Bioorg Med Chem Lett. 2011 Aug 15;21(16):4823-7. Epub 2011 Jun 29. PMID:21764580 From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See Also Glycogen synthase kinase 3

spinqualitylabelsall models 3zrk, resolution 2.37Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image