4mzp

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MazF from S. aureus crystal form III, C2221, 2.7 AMazF from S. aureus crystal form III, C2221, 2.7 A

Structural highlights

4mzp is a 8 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Related:4mzm, 4mzt, 2mf2
Resources:FirstGlance, OCA, RCSB, PDBsum

Publication Abstract from PubMed

mazEF modules encode toxin-antitoxin pairs that are involved in the bacterial stress response through controlled and specific degradation of mRNA. Staphylococcus aureus MazF and MazE constitute a unique toxin-antitoxin module under regulation of the sigB operon. A MazF-type mRNA interferase is combined with an antitoxin of unknown fold. Crystals of S. aureus MazF (SaMazF) were grown in space group P2(1)2(1)2(1). The crystals diffracted to 2.1 A resolution and are likely to contain two SaMazF dimers in the asymmetric unit.

Crystallization of the Staphylococcus aureus MazF mRNA interferase.,Zorzini V, Haesaerts S, Donegan NP, Fu Z, Cheung AL, van Nuland NA, Loris R Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):386-9. doi:, 10.1107/S1744309111000571. Epub 2011 Feb 25. PMID:21393849[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

  1. Zorzini V, Haesaerts S, Donegan NP, Fu Z, Cheung AL, van Nuland NA, Loris R. Crystallization of the Staphylococcus aureus MazF mRNA interferase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Mar 1;67(Pt 3):386-9. doi:, 10.1107/S1744309111000571. Epub 2011 Feb 25. PMID:21393849 doi:http://dx.doi.org/10.1107/S1744309111000571

4mzp, resolution 2.70Å

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