2c0t
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SRC FAMILY KINASE HCK WITH BOUND INHIBITOR A-641359
OverviewOverview
We describe the identification, SAR, and pharmacology of the src-family, selective lck inhibitor A-770041 that prolongs the survival of major, histocompatibility mismatched allografts in models of solid organ, transplant rejection for greater than 65 days.
About this StructureAbout this Structure
2C0T is a [Single protein] structure of sequence from [Homo sapiens] with CA and L3G as [ligands]. Active as [Transferred entry: 2.7.10.1 and 2.7.10.2], with EC number [2.7.1.112]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
ReferenceReference
Discovery of A-770041, a src-family selective orally active lck inhibitor that prevents organ allograft rejection., Burchat A, Borhani DW, Calderwood DJ, Hirst GC, Li B, Stachlewitz RF, Bioorg Med Chem Lett. 2006 Jan 1;16(1):118-22. Epub 2005 Oct 10. PMID:16216497
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- Homo sapiens
- Single protein
- Transferred entry: 2.7.10.1 and 2.7.10.2
- Borhani, D.W.
- Burchat, A.
- Calderwood, D.J.
- Hirst, G.C.
- Li, B.
- Loew, A.
- CA
- L3G
- Alternative initiation
- Atp-binding
- Kinase
- Lipoprotein
- Myristate
- Nucleotide-binding
- Palmitate
- Phosphorylation
- Sh2 domain
- Sh3 domain
- Transferase
- Tyrosine-protein kinase