4py0
Crystal structure of P2Y12 receptor in complex with 2MeSATPCrystal structure of P2Y12 receptor in complex with 2MeSATP
Structural highlights
Disease[P2Y12_HUMAN] Resistance to clopidogrel in myocardial infarction, cerebrovascular accident, oblitering arteriopathy of the lower limbs;P2Y12 defect. The disease is caused by mutations affecting the gene represented in this entry. Function[P2Y12_HUMAN] Receptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Not activated by UDP and UTP. Involved in platelet aggregation. References |
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OCACategories:
- Cherezov, V.
- GPCR, GPCR Network.
- Gao, Z G.
- Han, G W.
- Jacobson, K A.
- Jiang, H.
- Katritch, V.
- Li, T.
- Ma, L.
- Muller, C E.
- Paoletta, S.
- Stevens, R C.
- Wu, B.
- Yang, H.
- Zhang, D.
- Zhang, J.
- Zhang, K.
- Zhang, W.
- Zhao, Q.
- Gpcr
- Gpcr network
- Membrane
- Membrane protein
- Partial agonist-bound
- Platelet activation
- Psi-biology
- Purinergic receptor p2y12
- Signaling membrane protein
- Signaling protein-nucleotide complex
- Structural genomic