2a8a
Crystal structure of Clostridium botulinum neurotoxin serotype F light chainCrystal structure of Clostridium botulinum neurotoxin serotype F light chain
Template:ABSTRACT PUBMED 16128577
FunctionFunction
[BXF_CLOBO] Botulinum toxin acts by inhibiting neurotransmitter release. It binds to peripheral neuronal synapses, is internalized and moves by retrograde transport up the axon into the spinal cord where it can move between postsynaptic and presynaptic neurons. It inhibits neurotransmitter release by acting as a zinc endopeptidase that catalyzes the hydrolysis of the '58-Gln-|-Lys-59' bond of synaptobrevins-1 and -2.
About this StructureAbout this Structure
2a8a is a 1 chain structure with sequence from "bacillus_botulinus"_van_ermengem_1896 "bacillus botulinus" van ermengem 1896. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Agarwal R, Binz T, Swaminathan S. Structural analysis of botulinum neurotoxin serotype F light chain: implications on substrate binding and inhibitor design. Biochemistry. 2005 Sep 6;44(35):11758-65. PMID:16128577 doi:10.1021/bi0510072