Strictosidine Synthase

spinqualitylabelsall models PDB ID 2fp8 Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

strictosidine synthase (EC 4.3.3.2) is an enzyme that catalyzes the piectet spengler chemical reaction

tryptamine + secologanin <--> 3-alpha(S)-strictosidine + H2O

Thus, the two substrates of this enzyme are 3-alpha(S)-strictosidine and H2O, whereas its two products are tryptamine and secologanin.

This enzyme belongs to the family of lyases, specifically amine lyases, which cleave carbon-nitrogen bonds. The systematic name of this enzyme class is 3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming). Other names in common use include strictosidine synthetase, STR, and 3-alpha(S)-strictosidine tryptamine-lyase. This enzyme participates in terpenoid biosynthesis and indole and ipecac alkaloid biosynthesis.