4c3k

Structure of mixed PII-ADP complexes from S. elongatusStructure of mixed PII-ADP complexes from S. elongatus

Template:ABSTRACT PUBMED 24519945

FunctionFunction

[GLNB_SYNE7] P-II indirectly controls the transcription of the GS gene (glnA). P-II prevents NR-II-catalyzed conversion of NR-I to NR-I-phosphate, the transcriptional activator of glnA. When P-II is phosphorylated, these events are reversed. In nitrogen-limiting conditions, when the ratio of Gln to 2-ketoglutarate decreases, P-II is phosphorylated which allows the deadenylation of glutamine synthetase (GS), thus activating the enzyme.

About this StructureAbout this Structure

4c3k is a 6 chain structure with sequence from Pcc 6301. Full crystallographic information is available from OCA.

ReferenceReference

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↑ Zeth K, Fokina O, Forchhammer K. Structural Basis and Target-Specific Modulation of ADP Sensing by the Synechococcus elongatus PII Signaling Protein. J Biol Chem. 2014 Feb 11. PMID:24519945 doi:http://dx.doi.org/10.1074/jbc.M113.536557

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OCA

[1] Zeth K, Fokina O, Forchhammer K. Structural Basis and Target-Specific Modulation of ADP Sensing by the Synechococcus elongatus PII Signaling Protein. J Biol Chem. 2014 Feb 11. PMID:24519945 doi:http://dx.doi.org/10.1074/jbc.M113.536557

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