Preprotein translocase

Preprotein translocase (PPT) is responsible for the recognition and membrane translocation of preproteins. PPT contains receptors and import motor. The translocase pathway contains a chaperone protein – SecB; an integral membrane complex – SecY, SecE, SecG; proteins promoting the release of the mature peptide into the periplasm – SecD, SecF; and ATPase unit - SecA. For more details see SecA PBD motions.

3D structures of preprotein translocase3D structures of preprotein translocase

Updated on 13-April-2014

1rh5, 1rhz – MjPPT SecY + SecE + SecB – Methanocaldococcus jannaschii
2akh, 2aki – EcPPT SecY + SecE + SecG – Escherichia coli - CryoEM
2yxq, 2yxr – MjPPT SecY + SecE + SecG
3mp7 – PPT SecY + SecE – Pyrococcus furiosus
3dkn – PPT SecY + SecE + SecG + RNA – dog - CryoEM
3din – TmPPT SecY + SecE + SecG + SecA – Thermotoga maritima
2zjs – TtPPT SecY + SecE + antibody – Thermus thermophilus
2zqp – TtPPT SecY + SecE
3dl8 – PPT SecY + SecE + SecA + SecG – Aquifex aeolicus - CryoEM
3bo0, 3bo1 – EcPPT SecY + SecE + SecG + 23S ribosomal RNA - CryoEM
3kcr, 3j45, 3j46 – EcPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM
1vvk – MjPPT SecY + SecE + SecG + large ribosomal subunit - CryoEM
3j01 – EcPPT SecY + SecE + large ribosomal subunit - CryoEM

PPT SecA

1m6n, 1tf5, 2ibm – BsPPT SecA – Bacillus subtilis
3iqm, 3iqy – BsPPT SecA (mutant)
1tm6 – EcPPT SecA C terminal - NMR
2ipc – TtPPT SecA
3jux – TmPPT SecA
2fsf – EcPPT SecA
2fsf – EcPPT SecA
3bxz – EcPPT SecA dead motor domains (mutant)
1nl3 – MtPPT SecA – Mycobacterium tuberculosis

PPT SecA complex

1m74, 1tf2 – BsPPT SecA + Mg + ADP
1ozb – PPT SecA C terminal + SecB - Haemophilus influenzae
2fsh – EcPPT SecA + AMPPNP
2fsi – EcPPT SecA + ADP
2fsg – EcPPT SecA + ATP
2vda – EcPPT SecA + maltoporin signal peptide - NMR
3jv2 – BsPPT SecA + peptide
1nkt – MtPPT SecA + ADP

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky