4omc
X-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-AmbaX-ray structure of human furin in complex with the competitive inhibitor meta-guanidinomethyl-Phac-RVR-Amba
Template:ABSTRACT PUBMED 24666235
FunctionFunction
[FURIN_HUMAN] Furin is likely to represent the ubiquitous endoprotease activity within constitutive secretory pathways and capable of cleavage at the RX(K/R)R consensus motif.[1]
About this StructureAbout this Structure
4omc is a 12 chain structure. Full crystallographic information is available from OCA.
ReferenceReference
- ↑ Dahms SO, Hardes K, Becker GL, Steinmetzer T, Brandstetter H, Than ME. X-ray Structures of Human Furin in Complex with Competitive Inhibitors. ACS Chem Biol. 2014 Apr 1. PMID:24666235 doi:http://dx.doi.org/10.1021/cb500087x
- ↑ Takahashi S, Kasai K, Hatsuzawa K, Kitamura N, Misumi Y, Ikehara Y, Murakami K, Nakayama K. A mutation of furin causes the lack of precursor-processing activity in human colon carcinoma LoVo cells. Biochem Biophys Res Commun. 1993 Sep 15;195(2):1019-26. PMID:7690548 doi:http://dx.doi.org/10.1006/bbrc.1993.2146