Phosphocarrier protein

Phosphocarrier protein HPr (HPr) is a component of the sugar phosphotransferase system. The system catalyses the phosphorylation of sugars during their translocation across cell membrane. A phosphoryl group is transferred from phosphoenolpyruvate via several enzymes (EI, EII) to HPr. A conserved histidine in the N terminal of HPr is the acceptor of the phosphate. In Gram-positive bacteria HPr there is a conserved serine which is phosphorylated.

3D structures of phosphocarrier protein HPr3D structures of phosphocarrier protein HPr

Updated on 06-April-2014

2hpr - BsHPr (mutant) – Bacillus subtilis
2hid - BsHPr (mutant) – NMR
1jem - BsHPr (mutant) with phosphohistidine – NMR
1sph – BsHPr
1poh – EcHPr – Escherichia coli
1opd, 1cm2, 1cm3, 3ccd - EcHPr (mutant)
1hdn - EcHPr – NMR
1pfh - EcHPr with phosphohistidine – NMR
1ptf - EfHPr – Enterococcus faecalis
1qfr - EfHPr – NMR
1fu0 - EfHPr with phosphoserine
1pch – HPr – Mycoplasma capricolum
1qr5 - ScHPr – Staphylococcus carnosus - NMR
1txe - ScHPr (mutant) – NMR
1ka5 - HPr – Staphylococcus aureus - NMR
1y4y – GsHPr – Geobacillus stearothermophilus
1y50, 1y51 - GsHPr (mutant)
3ihs – HPr – Bacillus anthracis

HPr complexHPr complex

2jel - EcHPr + antibody
3eze, 3ezb, 3eza - EcHPr + EI N terminal + PO3 – NMR
2xdf - EcHPr + EI N terminal – NMR
1ggr, 1j6t, 1vrc - EcHPr + EII N terminal + PO3 – NMR
2lrk, 2lrl - EcHPr + EII N terminal – NMR
1kkl - BsHPr (mutant) + HPrK
1kkm - BsHPr (mutant) with phosphoserine + HPrK/P
2fep - BsHPr with phosphoserine + BsCcpA
1rzr – BmHPr with phosphoserine + BmCcpA + DNA - Bacillus megaterium
2oen - BmHPr with phosphoserine + BmCcpA
2nzu - BmHPr with phosphoserine + BmCcpA + glucose-6-phosphate
2nzv - BmHPr with phosphoserine + BmCcpA + fructose-1,6-diphosphate
3oqm, 3oqn, 3oqo - BsHPr with phosphoserine + BsCcpA + DNA

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky, Joel L. Sussman